Just bought a E345, find it great for music playback. Very solid sound quality (better than the Clip+ I had) Decent EQ, good tactile controls. Price can't be beat either. The E series is basically the S series without the built in speakers (right down to identical SQ)
Included earbuds are lacking, so I grabbed a pair of RE2 and a E5 to pair up with it.
The E series seems to be mainly for people who was an affordable DAP and who don't care about extra features. Just be sure the replace the included earbuds