Originally Posted by saratoga
If you remove the tags you will lose all info in the tags, so no title and artist.
But thats not what hes talking about. He said to remove all the extra tags that aren't needed (ID3v1, APE, etc). I doubt this really helps, but trimming extra crap out of the ID3v2 tags probably does, since it'll save a lot of time digging through files to parse them.
Per the recommendations in this thread, I used MediaMonkey to clean the tags in my MP3s and it definitely reduced the "refreshing media" time on my Sansa Fuze. It used to take more than 10 minutes, now it takes less than 5 minutes.